The role of metastasis-associated protein 1 in prostate cancer progression.

TitleThe role of metastasis-associated protein 1 in prostate cancer progression.
Publication TypeJournal Article
Year of Publication2004
AuthorsHofer MD, Kuefer R, Varambally S, Li H, Ma J, Shapiro GI, Gschwend JE, Hautmann RE, Sanda MG, Giehl K, Menke A, Chinnaiyan AM, Rubin MA
JournalCancer Res
Volume64
Issue3
Pagination825-9
Date Published2004 Feb 1
ISSN0008-5472
KeywordsAdult, Aged, Aged, 80 and over, Blotting, Western, Disease Progression, Humans, Immunohistochemistry, Male, Microfilament Proteins, Middle Aged, Neoplasm Proteins, Neoplasm Recurrence, Local, Oligonucleotide Array Sequence Analysis, Prostatectomy, Prostatic Neoplasms, RNA, Messenger, Tumor Markers, Biological
Abstract

Distinguishing aggressive prostate cancer from indolent disease represents an important clinical challenge, as current therapy requires over treating men with prostate cancer to prevent the progression of a few cases. Expression of the metastasis-associated protein 1 (MTA1) has previously been found to be associated with progression to the metastatic state in various cancers. Analyzing DNA microarray data, we found MTA1 to be selectively overexpressed in metastatic prostate cancer compared with clinically localized prostate cancer and benign prostate tissue. These results were validated by demonstrating overexpression of MTA1 in metastatic prostate cancer by immunoblot analysis. MTA1 protein expression was evaluated by immunohistochemistry in a broad spectrum of prostate tumors with tissue microarrays containing 1940 tissue cores from 300 cases. Metastatic prostate cancer demonstrated significantly higher mean MTA1 protein expression intensity (score = 3.4/4) and percentage of tissue cores staining positive for MTA1 (83%) compared with clinically localized prostate cancer (score = 2.8/4, 63% positive cores) or benign prostate tissue (score = 1.5/4, 25% positive cores) with a mean difference of 0.54 and 1.84, respectively (P < 0.00001 for both). Paradoxically, for localized disease, higher MTA1 protein expression was associated with lower rates of prostate specific antigen recurrence after radical prostatectomy for localized disease. In summary, this study identified an association of MTA1 expression and prostate cancer progression.

Alternate JournalCancer Res.
PubMed ID14871807
Grant ListCA42182 / CA / NCI NIH HHS / United States
CA58684 / CA / NCI NIH HHS / United States
CA90598 / CA / NCI NIH HHS / United States
CA97063 / CA / NCI NIH HHS / United States
P50CA69568 / CA / NCI NIH HHS / United States