Submitted by thm2008 on November 3, 2015 - 4:16pm
| Title | Molecular archeology: unearthing androgen-induced structural rearrangements in prostate cancer genomes. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Demichelis F, Garraway LA, Rubin MA |
| Journal | Cancer Cell |
| Volume | 23 |
| Issue | 2 |
| Pagination | 133-5 |
| Date Published | 2013 Feb 11 |
| ISSN | 1878-3686 |
| Abstract | In this issue of Cancer Cell, Weischenfeldt and colleagues report on the whole genome sequencing of 11 early-onset prostate cancers. Compared to elderly onset prostate cancer, these tumors demonstrate enrichment for androgen-driven structural rearrangements involving ETS family genes. This study confirms observations that prostate cancer manifests discrete genomic subclasses. |
| DOI | 10.1016/j.ccr.2013.01.019 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 23410968 |
| PubMed Central ID | PMC3630373 |
| Grant List | R01 CA125612 / CA / NCI NIH HHS / United States U01CA111275 / CA / NCI NIH HHS / United States |