An emerging role for cytopathology in precision oncology.

TitleAn emerging role for cytopathology in precision oncology.
Publication TypeJournal Article
Year of Publication2016
AuthorsPauli C, Puca L, Mosquera JMiguel, Robinson BD, Beltran H, Rubin MA, Rao RA
JournalCancer Cytopathol
Date Published2016 Mar

Precision medicine is an emerging field in medicine for disease prevention and treatment that takes into account the individual variability in genes, environment, and lifestyle for each individual patient. The authors have developed a special program as part of the Englander Institute for Precision Medicine to grow patient-derived, 3-dimensional tumor organoids for tumor-specific drug testing, tailoring treatment strategies, and as models for studying drug resistance. Routine cytology preparations represent a cost-effective and powerful tool to aid in performing molecular testing in the age of personalized medicine. In this commentary, the platforms used for the characterization and validation of patient-derived, 3-dimensional tumor organoids are outlined and discussed, and the role of cytology as a cost-effective and powerful quality-control measure is illustrated. Cancer Cytopathol 2016;124:167-173. © 2015 American Cancer Society.

Alternate JournalCancer Cytopathol
PubMed ID26641771