Beyond PSA: the next generation of prostate cancer biomarkers.

TitleBeyond PSA: the next generation of prostate cancer biomarkers.
Publication TypeJournal Article
Year of Publication2012
AuthorsPrensner JR, Rubin MA, Wei JT, Chinnaiyan AM
JournalSci Transl Med
Volume4
Issue127
Pagination127rv3
Date Published2012 Mar 28
ISSN1946-6242
KeywordsHumans, Male, Prostate-Specific Antigen, Prostatic Neoplasms, Tumor Markers, Biological
Abstract

Since the introduction of serum prostate-specific antigen (PSA) screening 25 years ago, prostate cancer diagnosis and management have been guided by this biomarker. Yet, PSA has proven controversial as a screening assay owing to several inherent limitations. The next wave of prostate cancer biomarkers has emerged, introducing new assays in serum and urine that may supplement or, in time, replace PSA because of their higher cancer specificity. This expanding universe of biomarkers has been facilitated, in large part, by new genomic technologies that have enabled an unbiased look at cancer biology. Such efforts have produced several notable success stories that involve rapidly moving biomarkers from the bench to the clinic. However, biomarker research has centered on disease diagnostics, rather than prognosis and prediction, which would address disease management. The development of biomarkers to stratify risk of prostate cancer aggressiveness at the time of screening remains the greatest unmet clinical need in prostate cancer. We review the current state of prostate cancer biomarker research, including the PSA revolution, its impact on early cancer detection, the recent advances in biomarker discovery, and the future efforts that promise to improve clinical management of this disease.

DOI10.1126/scitranslmed.3003180
Alternate JournalSci Transl Med
PubMed ID22461644
PubMed Central IDPMC3799996
Grant List5U01 CA113913 / CA / NCI NIH HHS / United States
P50CA69568 / CA / NCI NIH HHS / United States
T32 CA009676 / CA / NCI NIH HHS / United States
U01 CA 11275 / CA / NCI NIH HHS / United States
U01 CA111275 / CA / NCI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
/ / Howard Hughes Medical Institute / United States