Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program.

TitleAndrogen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program.
Publication TypeJournal Article
Year of Publication2004
AuthorsShah RB, Mehra R, Chinnaiyan AM, Shen R, Ghosh D, Zhou M, Macvicar GR, Varambally S, Harwood J, Bismar TA, Kim R, Rubin MA, Pienta KJ
JournalCancer Res
Date Published2004 Dec 15
KeywordsAged, Aged, 80 and over, Autopsy, Cluster Analysis, Gene Expression Profiling, Humans, Immunophenotyping, Male, Middle Aged, Neoplasms, Hormone-Dependent, Prostatic Neoplasms, Protein Array Analysis, Tumor Markers, Biological

Understanding the biology of prostate cancer metastasis has been limited by the lack of tissue for study. We studied the clinical data, distribution of prostate cancer involvement, morphology, immunophenotypes, and gene expression from 30 rapid autopsies of men who died of hormone-refractory prostate cancer. A tissue microarray was constructed and quantitatively evaluated for expression of prostate-specific antigen, androgen receptor, chromogranin, synaptophysin, MIB-1, and alpha-methylacylCoA-racemase markers. Hierarchical clustering of 16 rapid autopsy tumor samples was performed to evaluate the cDNA expression pattern associated with the morphology. Comparisons were made between patients as well as within the same patient. Metastatic hormone-refractory prostate cancer has a heterogeneous morphology, immunophenotype, and genotype, demonstrating that "metastatic disease" is a group of diseases even within the same patient. An appreciation of this heterogeneity is critical to evaluating diagnostic and prognostic biomarkers as well as to designing therapeutic targets for advanced disease.

Alternate JournalCancer Res.
PubMed ID15604294
Grant ListCA 97063 / CA / NCI NIH HHS / United States
CA102872 / CA / NCI NIH HHS / United States
P50CA69568 / CA / NCI NIH HHS / United States
R01AG21404 / AG / NIA NIH HHS / United States